In contrast to bilaterian animals, non‐bilaterian mitochondrial genomes contain atypical genes, often attributed to horizontal gene transfer (HGT) as an ad hoc explanation. Although prevalent in plants, HGT into animal mitochondrial genomes is rare, lacking suitable explanatory models for their occurrence. HGT of the mismatch DNA repair gene (mtMutS) from giant viruses to octocoral (soft corals and their kin) mitochondrial genomes provides a model for how barriers to HGT to animal mitochondria may be overcome. A review of the available literature (...) suggests that this HGT was mediated by an alveolate endosymbiont infected with a lysogenic phycodnavirus that enabled insertion of the homing endonuclease containing mtMutS into octocoral mitochondrial genomes. We posit that homing endonuclease domains and similar selfish elements play a crucial role in such inter‐domain gene transfers. Understanding the role of selfish genetic elements in HGT has the potential to aid development of tools for manipulating animal mitochondrial DNA. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Deep neural networks (DNNs) have had extraordinary successes in classifying photographic images of objects and are often described as the best models of biological vision. This conclusion is largely based on three sets of findings: (1) DNNs are more accurate than any other model in classifying images taken from various datasets, (2) DNNs do the best job in predicting the pattern of human errors in classifying objects taken from various behavioral datasets, and (3) DNNs do the best job in predicting (...) brain signals in response to images taken from various brain datasets (e.g., single cell responses or fMRI data). However, these behavioral and brain datasets do not test hypotheses regarding what features are contributing to good predictions and we show that the predictions may be mediated by DNNs that share little overlap with biological vision. More problematically, we show that DNNs account for almost no results from psychological research. This contradicts the common claim that DNNs are good, let alone the best, models of human object recognition. We argue that theorists interested in developing biologically plausible models of human vision need to direct their attention to explaining psychological findings. More generally, theorists need to build models that explain the results of experiments that manipulate independent variables designed to test hypotheses rather than compete on making the best predictions. We conclude by briefly summarizing various promising modeling approaches that focus on psychological data. (shrink)

Does action always arise out of desire? G. F. Schueler examines this hotly debated topic in philosophy of action and moral philosophy, arguing that once two senses of "desire" are distinguished - roughly, genuine desires and pro attitudes - apparently plausible explanations of action in terms of the agent's desires can be seen to be mistaken. Desire probes a fundamental issue in philosophy of mind, the nature of desires and how, if at all, they motivate and justify our actions. At (...) least since Hume argued that reason "is and of right ought to be the slave of the passions," many philosophers have held that desires play an essential role both in practical reason and in the explanation of intentional action. G. F. Schueler looks at contemporary accounts of both roles in various belief-desire models of reasons and explanation and argues that the usual belief-desire accounts need to be replaced. Schueler contends that the plausibility of the standard belief-desire accounts rests largely on a failure to distinguish "desires proper," like a craving for sushi, from so-called "pro attitudes," which may take the form of beliefs and other cognitive states as well as desires proper. Schueler's "deliberative model" of practical reasoning suggests a different view of the place of desire in practical reason and the explanation of action. He holds that we can arrive at an intention to act by weighing the relevant considerations and that these may not include desires proper at all. (shrink)

Given the sordid history of injustices linking genetics to race and ethnicity, considerations of justice are central to ensuring the responsible development of precision medicine programmes around the world. While considerations of justice may be in tension with other areas of concern, such as scientific value or privacy, there are also tensions between different aspects of justice. This paper focuses on three particular aspects of justice relevant to this precision medicine: social justice, distributive justice and human rights. We describe the (...) implications of each for the use of race and ethnicity in precision medicine, and also how they intersect and potentially conflict with each another. By attending to these intersections, we aim to enrich and add nuance to debates over how best to proceed with precision medicine initiatives. (shrink)

Currently fashionable among critics of enlightenment thought is the charge that Kant's ethics fails to provide an adequate account of character and its formation in moral and political life. G. Felicitas Munzel challenges this reading of Kant's thought, claiming not only that Kant has a very rich notion of moral character, but also that it is a conception of systematic importance for his thought, linking the formal moral with the critical, aesthetic, anthropological, and biological aspects of his philosophy. The first (...) book to focus on character formation in Kant's moral philosophy, it builds on important recent work on Kant's aesthetics and anthropology, and brings these to bear on moral issues. Munzel traces Kant's multifaceted definition of character through the broad range of his writings, and then explores the structure of character, its actual exercise in the world, and its cultivation. An outstanding work of original textual analysis and interpretation, _Kant's Conception of Moral Character_ is a major contribution to Kant studies and moral philosophy in general. (shrink)

Quantum mechanics, which describes the behavior of subatomic particles, seems to challenge common sense. Waves behave like particles; particles behave like waves. You can tell where a particle is, but not how fast it is moving--or vice versa. An electron faced with two tiny holes will travel through both at the same time, rather than one or the other. And then there is the enigma of creation ex nihilo, in which small particles appear with their so-called antiparticles, only to disappear (...) the next instant in a tiny puff of energy. Since its inception, physicists and philosophers have struggled to work out the meaning of quantum mechanics. Some, like Niels Bohr, have responded to quantum mechanics' mysteries by replacing notions of position and velocity with probabilities. Others, like Einstein and Penrose, have disagreed and think that the entire puzzle reflects not a fundamental principle of nature but our own ignorance of basic scientific processes. Sneaking a Look at God's Cards offers the general reader a deep and real understanding of the problems inherent to the interpretation of quantum mechanics, from its inception to the present. The book presents a balanced overview of current debates and explores how the theory of quantum mechanics plays itself out in the real world. Written from the perspective of a leading European physicist, the book looks extensively at ideas from both sides of the Atlantic and also considers what philosophers have contributed to the scientific discussion of this field. Sneaking a Look at God's Cards sets out what we know about the endlessly fascinating quantum world, how we came to this understanding, where we disagree, and where we are heading in our quest to comprehend the seemingly incomprehensible. (shrink)

Contemporary religious studies contains many studies of Orthodox theology of the twentieth century, but there are almost no studies of the most prominent modern trend in Orthodox theology, neo-patristics. In particular, in the works of L. Voronkova, G. Gabinsky, M. Gordienko, Y. Kalinin, P. Kurochkin, I. Mozgovy, V. Molokov, M. Novikov, N. Petelinskaya, V. Chertikhin, A. Chertkov, a thorough analysis of tendencies was carried out Modernism of Orthodox theology of the Russian Church. Of these, only M. Novikov briefly criticizes the (...) views of V. Lossky, a representative of Neopatristics, but the researcher does not realize the originality of this trend in Orthodox theology. Especially the tendencies of the development of Orthodox theology of spiritual academic schools of the XIX-beg. XX century. M. Ivanov, M. Glubokovsky, I. Kondratieva, G. Pankov, O. Pechurina, O. Sarapin, L. Fokina were thoroughly researched, but these studies were usually conducted outside the context of all Orthodox theology of the XX century. (shrink)

This article presents evidence supporting the claim that ethical reasoning is a skill that can be taught and assessed. We propose a working definition of ethical reasoning as 1) the ability to identify, analyze, and weigh moral aspects of a particular situation, and 2) to make decisions that are informed and warranted by the moral investigation. The evidence consists of a description of an ethical reasoning education program—Ethical Reasoning in Action —designed to increase ethical reasoning skills in a variety of (...) situations and areas of life. ERiA is housed at a public, major comprehensive U.S. university—James Madison University—and assessment of the program focuses on interventions delivered prior to and during orientation for incoming first-year students. Findings indicate that the interventions measurably enhance the ability of undergraduate students to reason ethically. ERiA’s competency-targeted program and positive student learning outcomes offers a promising model for higher education ethics programs seeking to connect classroom learning in ethics to decision-making in everyday life. (shrink)

G. E. R. Lloyd explores the amazing diversity of views that humans have held on being, humanity, and understanding. In a cross-cultural study that ranges from ancient to modern times, he asks how far we are bound by the conceptual systems to which we belong, and explores topics such as ontology, morality, philosophy of language, and communication.

When seeing a jaguar, we can see all the spots on its mantle without seeing a determinate number, N, of spots on the mantle. How is this visual phenomenon possible? Philosophers have tried to provide a reliable answer to this question, by recruiting evidence from vision science about the way attention works. Here we push this idea forward, by suggesting that an alternative and less complex solution, with respect to the one proposed in the literature, is possible. In particular, we (...) argue that the puzzling visual phenomenon of 'seeing entities without seeing N-entities' strictly depends on the specific number of entities we are simultaneously attending to: a problematic scenario concerning this visual process arises only when the number of entities in the visual field exceeds a specific quantity. This depends, as we argue, on the fact that the nature of our visual content is modulated, in this perceptual scenario, by the limited way we can exercise visual attention on the properties of the objects of our perception. Differently from other accounts, our proposal allows us to properly define when and why such a problem arises, and explains why such a situation has traditionally been found to be so puzzling. Our idea is also well motivated by experimental results that so far have not been taken into account in the debate. (shrink)

In their recent article, Koplin, Gyngell and Savulescu (2019) assess the viability of the precautionary principle as a decision-making tool to determine whether and under what circumstances germline gene editing should proceed. While their survey of different forms of the precautionary principle is illuminating, the most novel contribution is a new account of the precautionary principle, what they dub the Sufficientarian Precautionary Principle (SPP). SPP is meant to avoid several problems with existing accounts, while comporting with at least some of (...) the intuitive force behind the general idea of the precautionary principle. However, as it is only one subsection of a larger paper, SPP is not fully worked out. In this brief response, I will flesh out some problems with SPP as a decision-making tool – particularly that there is a lack of adequate normative justification for adopting it. While this does not constitute a decisive refutation of the approach, SPP needs considerable refinement and clarification before it can be considered viable for use in decision-making. (shrink)

In previous work I argued against (i) the likelihood of finding a theoretically sound foundation for the linked/convergent distinction and (ii) the utility of the distinction even if a sound theoretical basis could be found. Here I subject Douglas Walton’s comprehensive discussion of the linked/convergent distinction found in Argument Structure: A Pragmatic Theory to careful scrutiny and argue that at best Walton’s theory remains incomplete and that attempts to fill out the details will run afoul of at least one of (...) the problems adduced above—i.e., result in either a theoretically unsound distinction or a theoretically sound, but unnecessary distinction. (shrink)

We tend to assume that our map of the intellectual disciplines is valid cross-culturally. G. E. R. Lloyd challenges this in relation to eight main areas of human endeavour, namely philosophy, mathematics, history, medicine, art, law, religion, and science, by examining how the disciplines were conceived and developed in different times and places.

Grote's powerful defence of Thrasyllus' canon should have taught us at least not to reject lightly any dialogue which, like the Hippias Maior, is there classed as genuine. The burden of proof lies with those who attack our dialogue. Raeder, Ritter, and Apelt consider it to be genuine, while Ast, Jowett, Horneffer, and Röllig declare against it, as also Gomperz, Zeller, and Lutoslawski.

This book explores the universe and its subsystems from the three lenses of evolutionary (diversifying), developmental (converging), and complex (adaptive) processes at all scales. It draws from prolific experts within the academic disciplines of complexity science, physical science, information and computer science, theoretical and evo-devo biology, cosmology, astrobiology, evolutionary theory, developmental theory, and philosophy. The chapters come from a Satellite Meeting, "Evolution, Development and Complexity" (EDC) hosted at the Conference on Complex Systems, in Cancun, 2017. The contributions will be peer-reviewed (...) and contributors from outside the conference will be invited to submit chapters to ensure full coverage of the topics. This book explores many issues within the field of EDC such as the interaction of evolutionary stochasticity and developmental determinism in biological systems and what they might teach us about these twin processes in other complex systems. This text will appeal to students and researchers within the complex systems and EDC fields.. (shrink)

Anscombe on thought, experience, sensation, and the ethics of virtue Gertrude Elizabeth Margaret Anscombe is one of analytical philosophy's most prominent figures, the founder of consequentialism, and a leading mind in the field of virtue ethics. Metaphysics and the Philosophy of Mind: The collected Philosophical Papers of G.E.M. Anscombe, Volume 2, is part of a multivolume compilation of her life's work, providing insight into the mind of a groundbreaking 20th century philosopher. This volume's work explores memory, intentionality, causality and time, (...) delving into the language, actions, and logic of perception, sensation, and more. (shrink)

The influence of Nazism on German culture was a key concern for many Anglo-American writers, who struggled to reconcile the many contributions of Germany to European civilization, with the barbarity of the new regime. In _German Literature Through Nazi Eyes_, H.G. Atkins gives an account of how the Nazis undertook a re-evaluation of German literature, making it sub-ordinate to their own interests. All reference to Jewish writers and influence was virtually eliminated, and key writers such as Goethe and Lessing were (...) re-interpreted. What was left was a military history that was avowedly militant and propagandist. (shrink)

Ch. 1. Metodologicheskie problemy sot︠s︡ialʹno-gumanitarnogo poznanii︠a︡ -- ch. 2. Metodologicheskie problemy istorii filosofii i ėstetiki.

Este ensayo presenta una visión de conjunto del modo en el cual el «giro» (Kehre) hacia el pensamiento ontohistórico, a medidados de los años ’30, impacta sobre la concepción aleteiológica que, siguiendo a E. Lask y E. Husserl, Heidegger elabora desde comienzos de los años ‘20 hasta Sein und Zeit. Sobre esa base, se ofrece también un intento de caracterización de la reformulación eventualista-kairológica de la aleteiología presentada en Beiträge zur Philosophie. La caracterización propuesta se lleva a cabo con arreglo (...) a la distinción entre un nivel metahistórico de consideración, que corresponde al intento de pensar el seren su verdad en términos de la noción de «acontecimiento» (Ereignis), y un nivel propiamente histórico de consideración, que corresponde a la «hermenéutica de los dos comienzos». El pensar que medita históricamente el ser en su verdad sólo puede ser fiel a la intrínseca movilidad del ser mismo, si se ejerce en y desde la quietud de la contención, como temple animímico fundamental. (shrink)

The Cambridge Capital Controversy was one of the most significant debates in Twentieth Century economics. First published in 1972, this book provides an accessible reconstruction of the controversy with detailed discussion of the major points raised by its primary protagonists: Piero Sraffa and Joan Robinson on the post-Keynesian side and Robert Solow and Paul Samuelson on the neo-classical side. The book is now considered to be a classic. This fiftieth anniversary edition comes with a new preface by the author and (...) two new afterwords that reflect on the author's contribution to the field and the significance of the book in the history of economics. Topics covered include the measurement of capital, the revival of interest in Irving Fisher's rate of return on investment, the double-switching debate, Sraffa's prelude to a critique of neoclassical theory, and the 'new' theories of the rate of profits in capitalist society. (shrink)